The Melidoni cave is located close to the Melidoni village and has a great archeological and historical significance. According to archeologists the cave was inhabited continuously from the Neolithic to the Late Roman period. In October 1823, 370 Melidoni citizen found refuge in the cave to escape the Ottomans. After some unsuccessful attempts of recapturing the cave, the Ottomans blocked the cave and light a fire. The bones of the victims are still kept in the central chamber of the cave.